ID TNFA_HUMAN STANDARD; PRT; 233 AA.
AC P01375;
DT 21-JUL-1986 (REL. 01, CREATED)
DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE)
DE TUMOR NECROSIS FACTOR PRECURSOR (TNF-ALPHA) (CACHECTIN).
GN TNFA.
OS HOMO SAPIENS (HUMAN).
OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC EUTHERIA; PRIMATES.
RN [1]
RP SEQUENCE FROM N.A.
RX MEDLINE; 87217060.
RA NEDOSPASOV S.A., SHAKHOV A.N., TURETSKAYA R.L., METT V.A.,
RA AZIZOV M.M., GEORGIEV G.P., KOROBKO V.G., DOBRYNIN V.N.,
RA FILIPPOV S.A., BYSTROV N.S., BOLDYREVA E.F., CHUVPILO S.A.,
RA CHUMAKOV A.M., SHINGAROVA L.N., OVCHINNIKOV Y.A.;
RL COLD SPRING HARB. SYMP. QUANT. BIOL. 51:611-624(1986).
RN [2]
RP SEQUENCE FROM N.A.
RX MEDLINE; 85086244.
RA PENNICA D., NEDWIN G.E., HAYFLICK J.S., SEEBURG P.H., DERYNCK R.,
RA PALLADINO M.A., KOHR W.J., AGGARWAL B.B., GOEDDEL D.V.;
RL NATURE 312:724-729(1984).
RN [3]
RP SEQUENCE FROM N.A.
RX MEDLINE; 85137898.
RA SHIRAI T., YAMAGUCHI H., ITO H., TODD C.W., WALLACE R.B.;
RL NATURE 313:803-806(1985).
RN [4]
RP SEQUENCE FROM N.A.
RX MEDLINE; 86016093.
RA NEDWIN G.E., NAYLOR S.L., SAKAGUCHI A.Y., SMITH D.H.,
RA JARRETT-NEDWIN J., PENNICA D., GOEDDEL D.V., GRAY P.W.;
RL NUCLEIC ACIDS RES. 13:6361-6373(1985).
RN [5]
RP SEQUENCE FROM N.A.
RX MEDLINE; 85142190.
RA WANG A.M., CREASEY A.A., LADNER M.B., LIN L.S., STRICKLER J.,
RA VAN ARSDELL J.N., YAMAMOTO R., MARK D.F.;
RL SCIENCE 228:149-154(1985).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
RX MEDLINE; 90008932.
RA ECK M.J., SPRANG S.R.;
RL J. BIOL. CHEM. 264:17595-17605(1989).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
RX MEDLINE; 91193276.
RA JONES E.Y., STUART D.I., WALKER N.P.;
RL J. CELL SCI. SUPPL. 13:11-18(1990).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
RX MEDLINE; 90008932.
RA ECK M.J., SPRANG S.R.;
RL J. BIOL. CHEM. 264:17595-17605(1989).
RN [9]
RP MUTAGENESIS.
RX MEDLINE; 91184128.
RA OSTADE X.V., TAVERNIER J., PRANGE T., FIERS W.;
RL EMBO J. 10:827-836(1991).
RN [10]
RP MYRISTOYLATION.
RX MEDLINE; 93018820.
RA STEVENSON F.T., BURSTEN S.L., LOCKSLEY R.M., LOVETT D.H.;
RL J. EXP. MED. 176:1053-1062(1992).
CC -!- FUNCTION: CYTOKINE WITH A WIDE VARIETY OF FUNCTIONS: IT CAN
CC CAUSE CYTOLYSIS OF CERTAIN TUMOR CELL LINES, IT IS IMPLICATED
CC IN THE INDUCTION OF CACHEXIA, IT IS A POTENT PYROGEN CAUSING
CC FEVER BY DIRECT ACTION OR BY STIMULATION OF IL-1 SECRETION, IT
CC CAN STIMULATE CELL PROLIFERATION & INDUCE CELL DIFFERENTIATION
CC UNDER CERTAIN CONDITIONS.
CC -!- SUBUNIT: HOMOTRIMER.
CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. ALSO EXISTS AS
CC AN EXTRACELLULAR SOLUBLE FORM.
CC -!- PTM: THE SOLUBLE FORM DERIVES FROM THE MEMBRANE FORM BY
CC PROTEOLYTIC PROCESSING.
CC -!- DISEASE: CACHEXIA ACCOMPANIES A VARIETY OF DISEASES, INCLUDING
CC CANCER AND INFECTION, AND IS CHARACTERIZED BY GENERAL ILL
CC HEALTH AND MALNUTRITION.
CC -!- SIMILARITY: BELONGS TO THE TUMOR NECROSIS FACTOR FAMILY.
DR EMBL; X02910; HSTNFA.
DR EMBL; M16441; HSTNFAB.
DR EMBL; X01394; HSTNFR.
DR EMBL; M10988; HSTNFAA.
DR PIR; B23784; QWHUN.
DR PIR; A44189; A44189.
DR PDB; 1TNF; 15-JAN-91.
DR PDB; 2TUN; 31-JAN-94.
DR MIM; 191160; 11TH EDITION.
DR PROSITE; PS00251; TNF.
KW CYTOKINE; CYTOTOXIN; TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL-ANCHOR;
KW MYRISTYLATION; 3D-STRUCTURE.
FT PROPEP 1 76
FT CHAIN 77 233 TUMOR NECROSIS FACTOR.
FT TRANSMEM 36 56 SIGNAL-ANCHOR (TYPE-II PROTEIN).
FT LIPID 19 19 MYRISTATE.
FT LIPID 20 20 MYRISTATE.
FT DISULFID 145 177
FT MUTAGEN 108 108 R->W: BIOLOGICALLY INACTIVE.
FT MUTAGEN 112 112 L->F: BIOLOGICALLY INACTIVE.
FT MUTAGEN 162 162 S->F: BIOLOGICALLY INACTIVE.
FT MUTAGEN 167 167 V->A,D: BIOLOGICALLY INACTIVE.
FT MUTAGEN 222 222 E->K: BIOLOGICALLY INACTIVE.
FT CONFLICT 63 63 F -> S (IN REF. 5).
FT STRAND 89 93
FT TURN 99 100
FT TURN 109 110
FT STRAND 112 113
FT TURN 115 116
FT STRAND 118 119
FT STRAND 124 125
FT STRAND 130 143
FT STRAND 152 159
FT STRAND 166 170
FT STRAND 173 174
FT TURN 183 184
FT STRAND 189 202
FT TURN 204 205
FT STRAND 207 212
FT HELIX 215 217
FT STRAND 218 218
FT STRAND 227 232
SQ SEQUENCE 233 AA; 25644 MW; 279986 CN;
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR
EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR
DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE
TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
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