GenBank/RefSeq Update Goals
    
      - Incremental update of mRNAs and ESTs for multiple species and
      assemblies based on daily updates from NCBI.
- Automatically run from cron, possibly every night.
- Only require manual intervention on non-recoverable errors or when a
      large cluster run is required to do a large alignment.
- Incremental across GenBank releases; don't force a full realignment
      every quarter.
- Allow removal of older genbank full releases (and still not force a
      full realignment).
- Avoid corruption of disk files and databases.
- Recover from failures state, automatically when possible, making
      manual recover easy.
- Allow restarting failed steps without restarting the entire
      process.
- Don't require the process to be run at defined intervals. When a run
      is done, data files will be updated to reflect the current state of the
      NCBI repository.
- Include HTS files in automated download process.