# Penalized Likelihood Estimation and Dynamic Prediction under the Joint Frailty-Copula Models Between Tumour Progression and Death for Meta-Analysis

## Documentation for package ‘joint.Cox’ version 2.14

- DESCRIPTION file.

## Help Pages

joint.Cox-package | Penalized Likelihood Estimation and Dynamic Prediction under the Joint Frailty-Copula Models Between Tumour Progression and Death for Meta-Analysis
dataOvarian | Meta-analytic data of ovarian cancer patients combining 4 independent studies.
dataOvarian1 | Data on time-to-recurrence and 158 gene expressions for 912 ovarian cancer patients from 4 independent studies.
dataOvarian2 | Data on time-to-death and 128 gene expressions for 912 ovarian cancer patients from 4 independent studies.
F.KM | Prediction of death using the Kaplan-Meier estimator
F.prediction | Dynamic prediction of death
F.window | Prediction of death
F.windows | Prediction of death
I.spline | I-Spline function
joint.Cox | Penalized Likelihood Estimation and Dynamic Prediction under the Joint Frailty-Copula Models Between Tumour Progression and Death for Meta-Analysis
jointCox.indep.reg | Penalized Likelihood Estimation under the Joint Cox Models Between Tumour Progression and Death for Meta-Analysis
jointCox.reg | Penalized Likelihood Estimation under the Joint Cox Models Between Tumour Progression and Death for Meta-Analysis
M.spline | M-Spline function
splineCox.reg | Likelihood cross-validation (LCV) for the Cox model with penalized splines