# Exploring Disease Similarity in Terms of Dysfunctional Regulatory Mechanisms

## Documentation for package ‘DSviaDRM’ version 1.0

- DESCRIPTION file.

## Help Pages

DSviaDRM-package | Exploring disease similarity in terms of dysfunctional regulation mechanisms
comDCGL | Sort out common DCGs and DCLs in multi-diseases
comDCGLplot | Visualization of common DCGs and DCLs
DCEA | Identify DCGs (Differentially Co-expressed Genes) and DCLs (Differentially Co-expressed Links) based on the 'Differential Co-Expression Analysis'
DCpathway | Calculate differential co-expression values (dCs) for each pathways
DS | Identification of disease similarity
DSviaDRM | Exploring disease similarity in terms of dysfunctional regulation mechanisms
expressionBasedfilter | Filter genes according to expression level
exprs1 | Real dataset pulled down from GEO (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22528)
exprs2 | Real dataset pulled down from GEO (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE35487)
exprs3 | Real dataset pulled down from GEO (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE9006)
pathways | The dataset of human pathways downloaded from two collections of MSigDB
tf2target | The dataset of human Transcription Factors regulate potential target genes
varianceBasedfilter | To filter genes according to expression variability