Package: httk
Version: 2.0.3
Date: 2020-09-23
Title: High-Throughput Toxicokinetics
Description: Generic models and chemical-specific data for simulation and
             statistical analysis of chemical toxicokinetics ("TK") as
             described by Pearce et al. (2017) <doi:10.18637/jss.v079.i04>.
             Chemical-specific in vitro data have been obtained from relatively
             high throughput experiments. Both physiologically-based ("PBTK")
             and empirical (for example, one compartment) "TK" models can be
             parameterized with the data provided for thousands of chemicals,
             multiple exposure routes, and various species. The models consist
             of systems of ordinary differential equations which are solved
             using compiled (C-based) code for speed. A Monte Carlo sampler is
             included, which allows for simulating human biological variability
             (Ring et al., 2017 <doi:10.1016/j.envint.2017.06.004>)
             and propagating parameter uncertainty. Calibrated methods are
             included for predicting tissue:plasma partition coefficients and
             volume of distribution
             (Pearce et al., 2017 <doi:10.1007/s10928-017-9548-7>).
             These functions and data provide a set of tools for
             in vitro-in vivo extrapolation ("IVIVE") of high throughput
             screening data (for example, Tox21, ToxCast) to real-world
             exposures via reverse dosimetry (also known as "RTK")
             (Wetmore et al., 2015 <doi:10.1093/toxsci/kfv171>).
Authors@R: c(
           person("John", "Wambaugh", email = "wambaugh.john@epa.gov", 
             role = c("aut", "cre"),
             comment = c(ORCID = "0000-0002-4024-534X")), 
           person("Robert", "Pearce", role = c("aut"),
             comment = c(ORCID = "0000-0003-3168-4049")), 
           person("Caroline", "Ring", email = "cring@toxstrategies.com", 
             role = c("aut"), comment = c(ORCID = "0000-0002-0463-1251")), 
           person("Greg", "Honda", email = "honda.gregory@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0001-7713-9850")), 
           person("Mark", "Sfeir", email = "sfeir.mark@epa.gov", 
             role = c("aut")), 
           person("Matt", "Linakis", email = "matthew.linakis.1@us.af.mil", 
             role = c("aut"), comment = c(ORCID = "0000-0003-0526-2395")), 
           person("Jimena", "Davis", role = c("ctb")), 
           person("James", "Sluka", email = "jsluka@indiana.edu", 
             role = c("ctb"), comment = c(ORCID = "0000-0002-5901-1404")), 
           person("Nisha", "Sipes", email = "nisha.sipes@nih.gov", 
             role = c("ctb"), comment = c(ORCID = "0000-0003-4203-6426")), 
           person("Barbara", "Wetmore", email = "wetmore.barbara@epa.gov", 
             role = c("ctb"), comment = c(ORCID = "0000-0002-6878-5348")), 
           person("Woodrow", "Setzer", role = c("ctb"),
             comment = c(ORCID = "0000-0002-6709-9186"))
           )
Depends: R (>= 2.10)
Imports: deSolve, msm, data.table, survey, mvtnorm, truncnorm, stats,
        graphics, utils, magrittr, purrr, methods
Suggests: ggplot2, knitr, rmarkdown, R.rsp, GGally, gplots, scales,
        EnvStats, MASS, RColorBrewer, TeachingDemos, classInt, ks,
        stringr, reshape, reshape2, gdata, viridis, CensRegMod,
        gmodels, colorspace, cowplot, ggrepel, dplyr, forcats, smatr,
        gtools, gridExtra
License: GPL-3
LazyData: true
Encoding: UTF-8
VignetteBuilder: knitr, R.rsp
RoxygenNote: 7.1.1
URL:
        https://www.epa.gov/chemical-research/rapid-chemical-exposure-and-dose-research
BugReports: https://github.com/USEPA/CompTox-ExpoCast-httk
NeedsCompilation: yes
Packaged: 2020-09-24 22:10:49 UTC; jwambaug
Author: John Wambaugh [aut, cre] (<https://orcid.org/0000-0002-4024-534X>),
  Robert Pearce [aut] (<https://orcid.org/0000-0003-3168-4049>),
  Caroline Ring [aut] (<https://orcid.org/0000-0002-0463-1251>),
  Greg Honda [aut] (<https://orcid.org/0000-0001-7713-9850>),
  Mark Sfeir [aut],
  Matt Linakis [aut] (<https://orcid.org/0000-0003-0526-2395>),
  Jimena Davis [ctb],
  James Sluka [ctb] (<https://orcid.org/0000-0002-5901-1404>),
  Nisha Sipes [ctb] (<https://orcid.org/0000-0003-4203-6426>),
  Barbara Wetmore [ctb] (<https://orcid.org/0000-0002-6878-5348>),
  Woodrow Setzer [ctb] (<https://orcid.org/0000-0002-6709-9186>)
Maintainer: John Wambaugh <wambaugh.john@epa.gov>
Repository: CRAN
Date/Publication: 2020-09-25 11:00:03 UTC
Built: R 3.6.2; x86_64-apple-darwin15.6.0; 2020-09-26 11:10:42 UTC; unix
Archs: httk.so.dSYM
