Package: dfpk
Type: Package
Title: Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for
        Phase I Clinical Trials
Version: 3.5.1
Date: 2018-11-07
Authors@R: c(person("Artemis", "Toumazi", email = "artemis.toumazi@gmail.com", role = c("cre", "aut")), 
			 person("Sarah", "Zohar", email = "sarah.zohar@inserm.fr", role = "aut"),
			 person("Moreno", "Ursino", email = "moreno.ursino@inserm.fr", role = "aut"),
			 person("Trustees of", "Columbia University", role = "cph", comment = "R/stanmodels.R"),
			 person("French National Institute of", "Health and Medical Research", role = "cph")
			 )
Maintainer: Artemis Toumazi <artemis.toumazi@gmail.com>
Copyright: stanmodels.R is copyright 2015, 2016, 2017 Trustees of
        Columbia University. All other files are copyright French
        National Institute of Health and Medical Research.
Description: Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods, proposed by Ursino et al, (2017) <doi:10.1002/bimj.201600084>, enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).
License: GPL (>= 3) | file LICENSE
Depends: R (>= 3.4.0), Rcpp (>= 0.12.11), rstan (>= 2.18.1)
Imports: ggplot2 (>= 2.0.0), dfcrm, methods, stats, graphics,
        grDevices, PK
LinkingTo: StanHeaders (>= 2.18.0), rstan (>= 2.18.1), BH (>= 1.66),
        Rcpp (>= 0.12.0), RcppEigen
RcppModules: stan_fit4logit_reg_pkcov_mod, stan_fit4cdf_reg_dtox_mod,
        stan_fit4logit_reg_pkpop_mod, stan_fit4cdf_reg_pktox_mod,
        stan_fit4logit_reg_pklogit_mod, stan_fit4reg_auc_mod
LazyData: true
NeedsCompilation: yes
SystemRequirements: GNU make
URL: http://github.com/artemis-toumazi/dfpk
BugReports: http://github.com/artemis-toumazi/dfpk/issues
RoxygenNote: 6.0.1
Packaged: 2018-11-07 20:54:16 UTC; artemistoumazi
Repository: CRAN
Date/Publication: 2018-11-09 15:20:06 UTC
Author: Artemis Toumazi [cre, aut],
  Sarah Zohar [aut],
  Moreno Ursino [aut],
  Trustees of Columbia University [cph] (R/stanmodels.R),
  French National Institute of Health and Medical Research [cph]
Built: R 3.5.0; x86_64-apple-darwin15.6.0; 2018-11-10 17:36:39 UTC; unix
Archs: dfpk.so.dSYM
