# Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials

## Documentation for package ‘dfpk’ version 3.5.1

- DESCRIPTION file.

## Help Pages

dfpk-package | Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials.
AUC.estim | Estimation of the area under the curve, AUC.
dfpk | Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials.
dose-class | An S4 class to perform parameter estimation at each step during a dose-finding trial.
dosefinding-class | An S4 class to represent a dosefinding results.
dtox | Dose finding method DTOX.
invlogit | Inverse logistic functions.
nextDose | Next dose determination of a phase I clinical trial.
nsim | Simulate a single or n prospective clinical trial(s) using the PK measure in the dose finding designs.
pk.estim | The pharmacokinetic's (PK) measure of exposure.
pkcov | Dose finding method PKCOV.
pkcrm | Dose finding method PKCRM.
pklogit | Dose finding method PKLOGIT.
pkpop | Dose finding method PKPOP.
pktox | Dose finding method PKTOX.
plot-method | The graphical representation of dose escalation for each patient in the trial.
plot-method | The graphical representation of dose-finding results.
plot-method | The graphical representation of the drug's concentration in the plasma at time t after the drug administration.
scen-class | An S4 class to represent a simulated scenarios.
show-method | S4 Methods for Function 'show'
show-methods | S4 Methods for Function 'show'
sim.data | Generate and store PK and toxicity data.
stan_f | The data stan_f includes all the Stan models that dfpk package uses.