Package: precautionary
Type: Package
Title: Safety Diagnostics for Dose-Escalation Trial Designs
Version: 0.2-1
Date: 2021-01-12
Authors@R: c(person("David C.", "Norris"
                   , role = c("aut", "cre", "cph")
                   , email = "david@precisionmethods.guru"
                   , comment = c(ORCID = "0000-0001-9593-6343")
                   ),
             person("Markus", "Triska"
                   , role = "ctb"
                   , email = "triska@metalevel.at"
                   )
            )
Maintainer: David C. Norris <david@precisionmethods.guru>
Depends: magrittr, escalation, data.table, R (>= 3.5.0)
Imports: methods, dplyr, rlang, stringr, knitr, kableExtra
Suggests: rmarkdown, bookdown, tufte, testthat, lattice, latticeExtra,
        dtpcrm
Description: Enhances various R packages that support the design and simulation
             of phase 1 dose-escalation trials, adding diagnostics to examine
             the safety characteristics of these designs in light of expected
             inter-individual variation in pharmacokinetics and pharmacodynamics.
             See Norris (2020b), "Retrospective analysis of a fatal dose-finding
             trial" <arXiv:2004.12755> and (2020c) "What Were They Thinking?
             Pharmacologic priors implicit in a choice of 3+3 dose-escalation design"
             <arXiv:2012.05301>.
URL: https://precisionmethods.guru/
License: MIT + file LICENSE
VignetteBuilder: knitr, rmarkdown
Encoding: UTF-8
NeedsCompilation: no
RoxygenNote: 7.1.1
Collate: 'data.R' 'enhance.R' 'exact.R' 'precautionary-package.R'
        'toxicity_generators.R' 'simulate_trials.R'
LazyData: true
Packaged: 2021-01-12 21:15:23 UTC; david
Author: David C. Norris [aut, cre, cph]
    (<https://orcid.org/0000-0001-9593-6343>),
  Markus Triska [ctb]
Repository: CRAN
Date/Publication: 2021-01-12 21:50:03 UTC
Built: R 4.0.2; ; 2021-01-13 12:50:06 UTC; unix
