# Safety Diagnostics for Dose-Escalation Trial Designs

## Documentation for package ‘precautionary’ version 0.2-1

- DESCRIPTION file.
- User guides, package vignettes and other documentation.
- Code demos. Use demo() to run them.

## Help Pages

precautionary-package | Safety Diagnostics for Dose-Escalation Trial Designs
as.data.table.exact | Convert an object of class c('exact','precautionary','simulations') to a data.table
as.data.table.precautionary | Convert an object of class c('precautionary','simulations') to a data.table
cohorts_of_n | Override 'cohorts_of_n' to include latent toxicity tolerances
exact | A wrapper function supporting exact simulation of dose-escalation trials.
extend | Extend an existing simulation, using one of several stopping criteria
format.safetytab | Format a phase 1 trial safety tabulation to show significant digits only
hyper_mtdi_lognormal | Hyperprior for lognormal MTDi distributions
hyper_mtdi_lognormal-class | Hyperprior for lognormal MTDi distributions
mtdi_lognormal | A lognormal MTDi distribution
mtdi_lognormal-class | A lognormal MTDi distribution
ordinalization | Ordinalizers
ordinalizer | Ordinalizers
ordinalizers | Ordinalizers
phase1_sim | Override 'escalation:::phase1_sim' to incorporate latent toxicity tolerances
plan | Plan
plot-method | Visualize an 'mtdi_distribution' object
plot-method | Visualize n samples from an 'mtdi_generator' object
precautionary | Safety Diagnostics for Dose-Escalation Trial Designs
print.exact | Specialize print method for objects of class 'simulations'
print.hyper | Specialize print method defined for class 'simulations'
print.precautionary | Specialize print method for objects of class 'simulations'
safety_kable | Output a 'kable' for a simulation summary of class 'safetytab'
simulate_trials | Simulate trials defined via package 'escalation'
simulate_trials-method | Simulate trials defined via package 'escalation'
simulation_function.u_i | Get a function that simulates dose-escalation trials using latent 'u_i'
summary.exact | Summarize an exact treatment of a dose-escalation design
summary.precautionary | Specialize a method defined in package 'escalation' for class 'simulations'
test_draw_samples | Test performance of 'draw_samples' function
todo | Plan
viola_dtp | Complete dose transition pathways (DTP) table for the VIOLA trial.