News about R package lcmm :
---------------------------


A detailed companion paper is available in Journal of Statistical Software: 

Proust-Lima C, Philipps V, Liquet B. Estimation of Extended Mixed Models Using Latent Classes and Latent Processes: The R Package lcmm. Journal of Statistical Software, Articles. 2017;78(2):1-56. 

https://www.jstatsoft.org/article/view/v078i02


Changes in Version 1.9.2 :

* event variable in joint models can be logical
* bug fixed in Jointlcmm with prior when there are missing data
* bug fixed in mpjlcmm : initial values were badly modified (with at least 3 dimensions)
* small bugs fixed in predictY with median=TRUE

Changes in Version 1.9.1 :

* parallel implementation of gridsearch function. Thanks to Raphael Peter for his suggestion.
* add condRE_Y option in predictYcond
* add median options in predictY
* corrections in Jointlcmm, multlcmm and mpjlcmm when prior is specified
* bugs fixed in some prediction functions
* small bugs fixed in the summary when some parameters are not estimated
* bug fixed in VarExpl with models including BM or AR
* bug fixed in update.mpjlcmm (variance matrix was not correct)
* manage infinite ppi in hlme
* correction of epsY type, URL in vignettes, data statements position



Changes in Version 1.8.1 :

* new function mpjlcmm for estimating joint latent class models with multiple markers and/or latent processes
* various post-fit functions for mpjlcmm objects
* new functions permut and xclass
* creation of vignettes, thanks to Samy Youbi for his help
* variable 'subject' must be numeric
* in plot(which='fit'), time intervals do not depend on subset
* add score test result in summarytable
* bug fixed in lcmm with prior
* bug fixed in Jointlcmm with infinite score test
* bug fixed in dynpred with TimeDepVar

Changes in Version 1.7.9 :

* bug in summary when the model did not converge
* bug in dynpred when draws=TRUE and only 1 horizon or 1 landmark, or when o covariates are included in the survival model, or when using factor
* bug in Jointlcmm when using B=m1
* bug in plot.predictY with CI
* bug in Jointlcmm when B=random(m1)


Changes in Version 1.7.8 :

* shades in plot.predictlink/L/Y
* subset in plot, which="fit"



Changes in Version 1.7.6 (2016-12-12):

* Small bugs identified and solved in multlcmm


Changes in Version 1.7.5 (2016-03-15):

* Small bugs identified and solved in multlcmm, predictY and predictL


Changes in Version 1.7.4 (2015-12-26):

* The package uses lazydata to automatically load the datasets of the package.

* 'jlcmm' and 'mlcmm' are shortcuts for functions 'Jointlcmm' and 'multlcmm', respectively.

* Function 'gridsearch' provides an automatic grid of departures for reducing the odds of converging towards a local maximum. 

* Initial values can be randomly generated from a model with 1 class (called m1 in next example) with option B=random(m1) in hlme, lcmm, multlcmm and Jointlcmm.


Changes in Version 1.7.3.0 (2015-10-23):


* Functions 'hlme', 'lcmm', 'multlcmm', 'Jointlcmm' now include a posfix option to specify parameters that should not be estimated.

* Functions 'lcmm', 'multlcmm', 'Jointlcmm' now include a partialH option to restrict the computation of the inverse of the Hessian matrix to a submatrix

* Functions 'hlme', 'lcmm', 'multlcmm', 'Jointlcmm' now allow optional vector B to be an estimated model (with G=1) to reduce calculation time of initial values.

* Bug identified and solved in calculation of subject-specific predictions in  'hlme', 'lcmm', 'multlcmm' and 'Jointlcmm' when cor is not NULL.

* Bug identified and solved in the calculation of confidence bands for individual dynamic predictions in dynpred with draws=T.

* Bug identified and solved in the calculation of the explained variance for multlcmm objects when cor is not NULL.



Changes in Version 1.7.1 & 1.7.2 (2015-02-27):


* Function plot now includes a which="fit" option to plot observed and predicted trajectories stemming from a hlme, lcmm, Jointlcmm or multlcmm object.

* Function 'predictlink' replaces deprecated function 'link.confint' 

* Function 'plot' gathers deprecated functions 'plot.linkfunction', 'plot.baselinerisk', 'plot.survival', 'plot.fit' together 



Changes in Version 1.7.0 (2015-02-13):

* The function 'Jointlcmm' now allows competing risks data for the survival part and is also available for non-Gaussian longitudinal data. All existing methods for Jointlcmm objects (except EPOCE and Diffepoce functions) are adapted to the new framework. 

* Functions 'link.confint', 'plot.linkfunction', 'predictL' are now available for Jointlcmm objects.

* The new functions 'incidcum' and 'plot.incidcum' respectively compute and plot the cumulative incidence associated to each competing event for Jointlcmm object.

* The new function 'fitY' computes the marginal predicted values of longitudinal outcomes in their natural scale for lcmm or multlcmm objects.

* Bug identified and solved in 'dynpred' function when used with a joint model assuming proportional hazards between latent classes.

* The Makevars file now allows compilation of the package with parallel make.



Changes in Version 1.6.5 & 1.6.6 (2014-09-10):

* bug solved regarding installation problem with parallel make



Changes in Version 1.6.4 (2014-04-11):

* The new functions 'dynpred' and 'plot.dynpred' respectively compute and plot individual dynamic predictions obtained from a joint latent class model estimated by Jointlcmm.

* The new function 'VarCovRE' computes the standard errors of the parameters of variance-covariance of the random effects for a hlme, lcmm, Jointlcmm or multlcmm object

* The new function 'WaldMult' computes multivariate Wald tests and Wald tests for combinations of parameters from hlme, lcmm, Jointlcmm or multlcmm object

* The new function 'VarExpl' computes the percentages of variance explained by the linear regression for a hlme, lcmm, Jointlclmm or multlcmm object

* The new functions 'estimates' and 'VarCov' get respectively all parameters estimated and their variance-covariance matrix for a hlme, lcmm, Jointlcmm or multlcmm object

* Function 'summary' now returns the table containing the results about the fixed effects in the longitudinal model 

* All plots consider now the ... options

* Functions plot.linkfunction and plot.predict have now an add argument

* Function multlcmm now allows "splines" or "Splines" specification for the link functions

* Functions 'lcmm' and 'multlcmm' now compute the transformations even if the maximum number of iterations is reached without convergence

* bug identified and solved in multlcmm when the response variables are not integers

* bug identified and solved in multlcmm when using contrast

* bug identified and solved in plot.linkfunction for the y axes positions

* bug identified and solved in hlme, lcmm, Jointlcmm and multlcmm when including interactions in 'mixture'.




Changes in Version 1.6.2 (2013-03-06):

* The new function 'multlcmm' now estimates latent process mixed models for multivariate curvilinear longitudinal outcomes (with link functions: linear, beta or splines). Various post-fit computation and output functions are also available including plot.linkfunction, predictY, predictL, etc

* All the functions hlme, lcmm, Jointlcmm include a 'cor' option for including a brownian motion or a first-order autoregressive error process in addition to the independent errors of measurement

* bug identified and solved in predictL, predictY and plot.predict when used with factor covariate


Changes in Version 1.5.8 (2012-10-01):

* bug identified and solved in predictY.lcmm when used with a 'splines' link function and an outcome with minimum value not at 0


Changes in Version 1.5.7 (2012-07-24):

* The function 'predictY' now computes the predicted values (possibly class-specific) of the longitudinal outcome not only from a lcmm object but also from a hlme or a Jointlcmm object for a specified profile of covariates.

* bug identified and solved in predictY.lcmm when used with a 'threshold' link function and a Monte Carlo method


Changes in Version 1.5.6 (2012-07-16):

* missing data handled in hlme, lcmm and Jointlcmm using 'na.action' with attributes 1 for 'na.omit' or 2 for 'na.fail'

* The new function 'predictY.lcmm' computes predicted values of a lcmm object in the natural outcome scale for a specified profile of covariates, and also provides confidence bands using a Monte Carlo method.

* bugs in epoce computation solved (with splines baseline risk function, and/or NaN values under solaris system)

* bug identified and solved in summary functions regarding the labels of covariate effects in peculiar cases


Changes in Version 1.5.2 (2012-04-06):

* improved variable specification in the estimating functions Jointlcmm, lcmm and hlme with 
	- categorical variables using factor() 
	- variables entered as functions using I() 
	- interaction terms using "*" and ":"

* computation of the predictive accuracy measure EPOCE from a Jointlcmm object either on the training data or on external data (post-fit functions epoce and Diffepoce)

* for discrete outcomes, lcmm function now computates the posterior discrete log-likelihood and the universal approximate cross-validation criterion (UACV)

* Jointlcmm now includes two parameterizations of I-splines and piecewise-constant baseline risks functions to ensure positive risks: either log/exp or sqrt/square (option logscale=).  



